cat no | io1007
ioGlutamatergic Neurons
GBA null/R159W
Human iPSC-derived Gaucher and Parkinson鈥檚 disease model
ioGlutamatergic Neurons GBA null/R159W are opti鈥憃x deterministically programmed glutamatergic neurons carrying a genetically engineered compound heterozygous mutation in the GBA gene encoding the glucocerebrosidase (GCase) enzyme. These cells offer a rapidly maturing, human cell model to investigate modulation of GCase expression.
Place your order
Confidently investigate your phenotype of interest across multiple clones with our disease model clone panel. Detailed characterisation data (below) and bulk RNA sequencing data (upon request) help you select specific clones if required.
Benchtop benefits
Make True Comparisons
Pair the ioDisease Model Cells with the genetically matched wild-type ioGlutamatergic Neurons to investigate the impact of the GBA mutation on molecular mechanisms and cell function.
Scalable
With opti-ox technology, we can make billions of consistently programmed cells, surpassing the demands of industrial workflows.
Quick
The disease model cells and isogenic control are experiment ready as early as 2 days post revival, and form structural neuronal networks at 11 days.
Highly characterised and defined
ioGlutamatergic Neurons GBA null/R159W express neuron-specific markers comparably to the isogenic control
Immunofluorescent staining on post-revival day 11 demonstrates similar homogenous expression of pan-neuronal proteins TUBB3 and MAP2 (upper panel) and glutamatergic neuron-specific transporter VGLUT2 (lower panel) in ioGlutamatergic Neurons GBA null/R159W compared to the isogenic control. 100X magnification.
ioGlutamatergic Neurons GBA null/R159W form structural neuronal networks by day 11
ioGlutamatergic Neurons GBA null/R159W mature rapidly and form structural neuronal networks over 11 days, when compared to the isogenic control. Day 1 to 11 post thawing; 100X magnification.
ioGlutamatergic Neurons GBA null/R159W demonstrate gene expression of neuronal and glutamatergic-specific markers following deterministic programming
Gene expression analysis demonstrates that ioGlutamatergic Neurons GBA null/R159W and the isogenic control (WT Control) lack the expression of pluripotency markers (NANOG and OCT4) at day 11, whilst robustly expressing pan-neuronal (TUBB3 and SYP) and glutamatergic specific (VGLUT1 and VGLUT2) markers, as well as the glutamate receptor GRIA4. Gene expression levels were assessed by RT-qPCR (data normalised to HMBS; cDNA samples of the parental human iPSC line (hiPSC) were included as reference). Data represents day 11 post-revival samples, n=2 replicates.
Disease-related GBA is expressed in ioGlutamatergic Neurons GBA null/R159W following deterministic programming
Gene expression analysis demonstrates that ioGlutamatergic Neurons GBA null/R159W and the isogenic control (WT Control) express the GBA gene encoding the glucocerebrosidase protein. Gene expression levels were assessed by RT-qPCR (data normalised to HMBS, cDNA samples of the parental human iPSC line (hiPSC) were included as reference). Data represents day 11 post-revival samples, n=2 replicates.
GBA protein is present in ioGlutamatergic Neurons GBA null/R159W at a lower level than the wild type control
A Western blot experiment confirmed the presence of the GBA protein in ioGlutamatergic Neurons GBA null/R159W at a lower level than in the wild-type ioGlutamatergic Neurons. Day 11 cell lysates were subjected to Western blotting (20 碌g protein in 40 碌l per lane) using 4-20% mini protean TGX stain-free gels. Proteins were transferred onto PVDF membranes using the Trans-Blot Turbo Transfer Pack, blocked for 10 minutes, incubated with primary antibodies (GBA Invitrogen MA5-26589, 1:2000; GAPDH Abcam ab8245, 1:5000), washed three times, incubated with HRP-labelled secondary antibodies, washed three times and signal visualised by electrochemiluminescence.
1= ioGlutamatergic Neurons (wild type), 2= ioGlutamatergic Neurons GBA null/R159W.
Cells arrive ready to plate
ioGlutamatergic Neurons GBA null/R159W are delivered in a cryopreserved format and are programmed to mature rapidly upon revival in the recommended media. The protocol for the generation of these cells is a two-phase process: Phase 1, Stabilisation for 4 days; Phase 2, Maintenance, during which the neurons mature. Phases 1 and 2 after revival of cells are carried out by the customer.
Industry leading seeding density
The recommended minimum seeding density is 30,000 cells/cm2, compared to up to 250,000 cells/cm2 for other similar commercially available products. One small vial can plate a minimum of 0.7 x 24-well plate, 1 x 96-well plate, or 1.5 x 384-well plates. This means every vial goes further, enabling more experimental conditions and more repeats, resulting in more confidence in the data.
(LinkedValues: [{hs_name=Developing next-generation in vitro phenotypic assays for Huntington鈥檚 disease by combining a precision reprogrammed hiPSC-derived disease model with high-density microelectrode arrays, hs_id=161727133271, hs_path=ioglutamatergic-neurons-htt-maxwell-crl, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=, width=600, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons%20HTT%2050CAGWT/a-HTT50CAGWT_Overlay__TUBB3(G)_MAP2(R)_DAPI(B)_%20(1).png, height=378}, year={label=2022, value=2022}, summary=<p>无忧短视频 | MaxWell Biosystems | Charles River Laboratories</p>
<p>2022</p>, date_published=1708560000000, sort_date=1668556800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=<p>无忧短视频 | MaxWell Biosystems | Charles River Laboratories</p>
<p>2022</p>
<p> </p>, listing_button_label=Download}, {hs_name=Sartorius application note - Advanced in vitro Modeling of Human iPSC-derived Neuronal Mono- and Co-cultures with Microglia, hs_id=177620758074, hs_path=sartorius-application-note-advanced-in-vitro-modeling-of-human-ipsc-derived-neuronal-mono-and-co-cultures-with-microglia, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=co culture low density progenitors compressed, width=1732, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/co%20culture%20low%20density%20progenitors%20compressed.png, height=970}, year={label=2024, value=2024}, summary=Trigg et al.,<br>Sartorius<br>2024, date_published=1725580800000, sort_date=1725580800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=Trigg et al.,<br>Sartorius<br>2024, listing_button_label=Download}, {hs_name=Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons, hs_id=180505546901, hs_path=glutamatergic-neuron-3d-neuronal-microtissues-inventia, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2024, value=2024}, summary=V1<br>2024<br>无忧短视频<br>Inventia, date_published=1728345600000, sort_date=1728345600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioAstrocytes, value=ioastrocytes}], media_contact=V1<br>2024<br>无忧短视频<br>Inventia, listing_button_label=Download}, {hs_name=Generating publishable neuroscience research in 12 weeks with ioGlutamatergic Neurons, hs_id=161746296926, hs_path=generating-publishable-neuroscience-research-in-12-weeks-with-glutamatergic-neurons, button_label=null, button_link=null, type={label=Case study, value=Case study}, thumbnail={alt_text=, width=2400, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Compressed%20Photos%20and%20Gifs/无忧短视频_case_study_Pic0012_WebRes.jpg, height=1600}, year={label=2024, value=2024}, summary=<p>Professor Deepak Srivastava</p>
<p>Professor of Molecular Neuroscience and Group Leader, MRC Centre for Developmental Disorders</p>
<p>King鈥檚 College London </p>, date_published=1710720000000, sort_date=1705276800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>V2</p>
<p>2024</p>
<p>无忧短视频</p>, listing_button_label=Download}, {hs_name=ioGlutamatergic Neurons , hs_id=161746296923, hs_path=glutamatergic-neurons, button_label=View brochure, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Brochures/无忧短视频-ioGlutamatergic%20Neurons-Brochure.pdf, type={label=Brochure, value=Brochure}, thumbnail={alt_text=, width=2550, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Discover%20ioCells/iowild-type/无忧短视频-ioGlutamatergic-Neurons-Day-14-Beta-III-Tubulin-staining-banner.jpg, height=1791}, year={label=2024, value=2024}, summary=<p>无忧短视频</p>, date_published=1713312000000, sort_date=1713312000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioAstrocytes, value=ioAstrocytes}, {label=Product information, value=Product information}], media_contact=null, listing_button_label=Download}, {hs_name=High Content Analysis of 2D and 3D cellular models for target and phenotypic drug discovery, hs_id=161961134487, hs_path=charles-river-poster-high-content-analysis-of-cellular-models, button_label=View poster, button_link=https://无忧短视频/hubfs/BitBio_April2021/pdf%20link/2020_Lachize-et-al_High-Content-Analysis-of-2D-and-3D-Cellular-Models_Charles-River.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2020, value=2020}, summary=<p>Lachize, et al</p>
<p>Courtesy of Charles River Laboratories</p>
<p>2020</p>, date_published=1706313600000, sort_date=1602806400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=null, listing_button_label=View}, {hs_name=Development and characterisation of a robust in vitro disease model to study tauopathies, hs_id=161961134488, hs_path=ftd-mapt-phenotype-poster-charles-river-mar23, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/SFN2022-Development-and-characterization-of-a-robust-in-vitro-disease-model-to-study-tauopathies.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1000, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/MAPT%20P301S/MAPT%20P301SP301S%20final%20homepage%20image.jpg, height=1400}, year={label=2022, value=2022}, summary=<p>Ritsma, et al</p>
<p>Charles River Laboratories & 无忧短视频</p>
<p>2022</p>, date_published=1708646400000, sort_date=1678924800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}], media_contact=null, listing_button_label=View}, {hs_name=Rapid and consistent generation of functional microglia from reprogrammed hiPSCs to study neurodegeneration and neuroinflammation, hs_id=161961134491, hs_path=poster-rapid_and_consistent_generation_of_functional_ipsc_derived_microglia, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/bitbio-ioMicroglia_poster-V7-press_SfN%202022.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1504, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Header%20images/Header%20Images%20-%20ICC%20only/Microglia%20blog%20email%20header%20format.png, height=850}, year={label=2022, value=2022}, summary=<p>Raman, et al</p>
<p>无忧短视频</p>
<p>2022</p>, date_published=1709251200000, sort_date=1669680000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=null, listing_button_label=View}, {hs_name=Modelling neurodegeneration: Human isogenic system to study FTD & ALS, hs_id=161961134492, hs_path=ftd-als-mapt-tdp-43-disease-models-adpd-2023-poster-mar23, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/bitbio_ioGlutamatergic%20Neurons%20MAPT%20TDP-43%20Disease%20Model%20poster_v2.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1966, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/MAPT%20N279K/N279K%20MAP2%20brightfield%20compressed%20rotated.png, height=1966}, year={label=2023, value=2023}, summary=<p>Oosterveen, et al</p>
<p>无忧短视频 & Charles River Laboratories</p>
<p>2023</p>, date_published=1709424000000, sort_date=1687478400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}], media_contact=null, listing_button_label=View}, {hs_name=Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer鈥檚 disease, hs_id=161961134495, hs_path=slas2024-ad-poster, button_label=null, button_link=null, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1800, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/Microglia%20hero%202%20resize%20brighten%20v2%20compress.png, height=1800}, year={label=2024, value=2024}, summary=Smith, et al. <br>无忧短视频<br>2024, date_published=1711065600000, sort_date=1708300800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=Smith et al. <br>无忧短视频<br>2024, listing_button_label=Download}, {hs_name=Lipid-Bilayer-Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions , hs_id=161968263464, hs_path=lipid-bilayer-supported-3d-printing-of-human-cerebral-cortex-cells-reveals-developmental-interactions, button_label=Read more, button_link=https://onlinelibrary.wiley.com/doi/10.1002/adma.202002183, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=666, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources/Resource-thumbs/resized/New%20Project%20(13).jpeg, height=428}, year={label=2020, value=2020}, summary=<p>Zhou L, et al </p>
<p><em>Advanced Science News</em></p>
<p>2020</p>
<p><a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">Using ioGlutamatergic Neurons</a></p>, date_published=1592092800000, sort_date=1598659200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Zhou L, et al</p>
<p><em>Advanced Science News</em></p>
<p>2020</p>
<p>Using <a href="/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Reprogramming the stem cell for a new generation of cures, hs_id=161968263465, hs_path=reprogramming-the-stem-cell-for-a-new-generation-of-cures, button_label=Read more, button_link=https://www.ddw-online.com/reprogramming-the-stem-cell-for-a-new-generation-of-cures-1459-202004/, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=2092, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/无忧短视频%20ioGlutamatergic%20Neurons%202022.jpg, height=1584}, year={label=2020, value=2020}, summary=<p>Davenport A, Frolov T & Kotter M</p>
<p><em>Drug Discovery World</em></p>
<p>2020</p>
<p> </p>
<p> </p>, date_published=1585872000000, sort_date=1597968000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioMotor Neurons, value=ioMotor Neurons}, {label=ioAstrocytes, value=ioAstrocytes}], media_contact=<p><span>Davenport A, Frolov T & Kotter M.</span></p>
<p><em>Drug Discovery World</em></p>
<p>2020</p>
<p> </p>
<p> </p>, listing_button_label=Read more}, {hs_name=Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes , hs_id=161968263466, hs_path=inducible-and-deterministic-forward-programming-of-human-pluripotent-stem-cells, button_label=Read more, button_link=https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30083-8, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=759, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/publication-Inducible-and-deterministic-colour.jpg, height=461}, year={label=2017, value=2017}, summary=<p>Pawlowski M et al<br><em>Stem Cell Reports</em></p>
<p>2017</p>, date_published=1491868800000, sort_date=1499385600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p><span>Pawlowski M, et al</span></p>
<p><em>Stem Cell Reports</em></p>
<p>2017</p>
<p> </p>, listing_button_label=Read more}, {hs_name=Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice, hs_id=161968263467, hs_path=compounds-co-targeting-kinases-in-axon-regulatory-pathways-promote-regeneration-and-behavioral-recovery-after-spinal-cord-injury-in-mice, button_label=Read more, button_link=https://pubmed.ncbi.nlm.nih.gov/35588791/, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=1871, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Publications/无忧短视频_single%20image_ioGlutamatergic%20Neurons%20Mah%20et%20al%202022.jpg, height=1417}, year={label=2022, value=2022}, summary=<p>Mah, et al</p>
<p><em>Experimental Neurology</em></p>
<p>2022</p>
<p>Using <a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, date_published=1652659200000, sort_date=1667260800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Mah, et al</p>
<p><em>Experimental Neurology</em></p>
<p>2022</p>
<p>Using <a href="/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Glutamatergic Neurons and Brain Cyst Formation , hs_id=161968263468, hs_path=glutamatergic-neurons-and-brain-cyst-formation, button_label=Read more, button_link=https://www.frontiersin.org/articles/10.3389/fcimb.2021.788303/full, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=2092, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/无忧短视频%20ioGlutamatergic%20Neurons%202022.jpg, height=1584}, year={label=2022, value=2022}, summary=<p>Bando, et al</p>
<p><em>Frontiers in Cellular and Infection Microbiology</em></p>
<p>2022</p>
<p>Using<a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank"> ioGlutamatergic Neurons</a></p>
<p> </p>
<p> </p>, date_published=1641859200000, sort_date=1667347200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Bando, et al<br><br><em>Frontiers in Cellular and Infection Microbiology</em></p>
<p>2022</p>
<p>Using <a href="/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Interferon-纬 exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression , hs_id=161968263469, hs_path=interferon-纬-exposure-of-human-ipsc-derived-neurons-alters-major-histocompatibility-complex-i-and-synapsin-protein-expression, button_label=Read more, button_link=https://www.frontiersin.org/articles/10.3389/fpsyt.2022.836217/full, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=3742, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Publications/无忧短视频%20ioGlutamatergic%20Neurons%20pavlinek%20et%20al%202022.jpg, height=2836}, year={label=2022, value=2022}, summary=<p>Pavinlek, et al</p>
<p><em>Frontiers in Psychiatry</em></p>
<p>2022</p>
<p>Using <a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>
<p> </p>
<p> </p>, date_published=1663113600000, sort_date=1667433600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Pavinlek, et al<br><br><em>Frontiers in Psychiatry</em></p>
<p>2022</p>
<p>Using <a href="/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication, hs_id=178039124124, hs_path=rewiring-of-the-promoter-nature-article, button_label=Read more, button_link=https://www.nature.com/articles/s41467-023-41919-x, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Chakraborty et al<br><em>Nature Communications</em><br>2023</p>
<p>Featuring <a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, date_published=1697155200000, sort_date=1697155200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Chakraborty et al<br><em>Nature Communications</em><br>2023</p>
<p>Featuring <a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=HNRNPH1 regulates the neuroprotective cold鈥恠hock protein RBM3 expression through poison exon exclusion, hs_id=178039124146, hs_path=hnrnph1-regulates-the-neuroprotective-cold-shock-protein-rbm3-expression-through-poison-exon-exclusion-article, button_label=Read more, button_link=https://www.embopress.org/doi/full/10.15252/embj.2022113168, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Qiaojin Lin et al</p>
<p><em>The EMBO Journal</em></p>
<p>2023</p>
<p>Featuring opti-ox powered hiPSC-derived <a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">glutamatergic neurons</a> with constitutive expression of Cas9</p>, date_published=1685404800000, sort_date=1685404800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Qiaojin Lin et al</p>
<p><em>The EMBO Journal</em></p>
<p>2023</p>
<p>Featuring opti-ox powered hiPSC-derived <a href="/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">glutamatergic neurons</a> with constitutive expression of Cas9</p>, listing_button_label=Read more}, {hs_name=Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons, hs_id=178046423390, hs_path=schizophrenia-risk-gene-znf804a-controls-ribosome-localization-and-synaptogenesis-in-developing-human-neurons-article, button_label=Read more, button_link=https://www.biorxiv.org/content/10.1101/2024.02.02.578424v1, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2024, value=2024}, summary=<p><span>Deepak P.</span><span> </span><span>Srivastava, et al</span></p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="/platform" rel="noopener" target="_blank">opti-ox </a>enabled glutamatergic neurons iPS cell line</p>, date_published=1706832000000, sort_date=1706832000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p><span>Deepak P.</span><span> </span><span>Srivastava, et al</span></p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="/platform" rel="noopener" target="_blank">opti-ox</a><sup> </sup>enabled glutamatergic neurons iPS cell line</p>, listing_button_label=Read more}, {hs_name=Circadian clocks in human cerebral organoids, hs_id=178051600304, hs_path=circadian-clocks-in-human-cerebral-organoids-article, button_label=Read more, button_link=https://www.biorxiv.org/content/10.1101/2024.02.20.580978v1.full, type={label=Publication, value=Publication}, thumbnail={alt_text=Hero image_CRISPR-Ready ioMicroglia, width=1422, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/Hero%20image_CRISPR-Ready%20ioMicroglia.png, height=1920}, year={label=2024, value=2024}, summary=<p>Rzechorzek, et al</p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="/platform" rel="noopener" target="_blank">opti-ox</a><sup> </sup>enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line</p>, date_published=1708473600000, sort_date=1708473600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=<p>Rzechorzek, et al</p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="/platform" rel="noopener" target="_blank">opti-ox</a><sup> </sup>enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line</p>, listing_button_label=Read more}, {hs_name=CRISPR and the Art of Perturbation Screening: Unbiased functional genomic screening meets the best human cellular models, hs_id=161968263475, hs_path=crispr-and-the-art-of-perturbation-screening-unbiased-functional-genomic-screening-meets-the-best-human-cellular-models, button_label=Explore ioCRISPR-Ready Cells, button_link=/iocrispr-ready, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/CRISPR%20and%20the%20Art%20of%20Perturbation%20Screening-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Kam Dhaliwal <span>| </span>SVP Strategic Alliances | 无忧短视频</p>
<p><br>Talk at ELRIG CRISPR in Drug Discovery</p>, date_published=1706140800000, sort_date=1636070400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioSensory Neurons, value=ioSensory Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Consistent and scalable human iPSC-derived cells for in vitro disease modelling and drug discovery, hs_id=161968263476, hs_path=consistent-and-scalable-human-ipsc-derived-cells-for-in-vitro-disease-modelling-and-drug-discovery, button_label=Explore ioCells, button_link=/discover-iocells, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=900, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/DDD_banner_square.jpeg, height=652}, year={label=2020, value=2020}, summary=<p>Kam Dhaliwal <span>| </span> SVP Strategic Alliances | 无忧短视频<br>Dr Thomas Moreau <span>|</span> Head of Research | 无忧短视频</p>
<p><br>Talk at ELRIG Drug Discovery Digital</p>, date_published=1706400000000, sort_date=1600905600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=null, listing_button_label=Watch now}, {hs_name=Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models, hs_id=161968263479, hs_path=precision-cellular-reprogramming-for-scalable-and-consistent-human-neurodegenerative-disease-models, button_label=Explore ioDisease Model Cells, button_link=/iodisease-models, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Tech%20Nets%20online%20symposium%20header%20(1).png, height=1260}, year={label=2023, value=2023}, summary=<p>Madeleine Garrett | Field Application Specialist | 无忧短视频</p>, date_published=1709078400000, sort_date=1681344000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}, {label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Industrialising Cellular Reprogramming: Leveraging opti-ox Technology to Manufacture Human Cells with Unprecedented Consistency, hs_id=161968263480, hs_path=industrialising-cellular-reprogramming-leveraging-opti-ox-technology-to-manufacture-human-cells-with-unprecedented-consistency, button_label=null, button_link=null, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1024, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Resources/video/Squarespace+Thumbnail+Template+-+AM23-01-01-01.png, height=768}, year={label=2023, value=2023}, summary=<p>Innovation showcase talk at ISSCR</p>
<p>Marius Wernig MD, PhD | Stanford </p>
<p>Mark Kotter, MD, PhD | 无忧短视频</p>, date_published=1709683200000, sort_date=1688083200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}], media_contact=<p>V1<br><br>2023<br><br>ISSCR 2023</p>, listing_button_label=Watch now}, {hs_name=ioGlutamatergic Neurons Wild Type and related disease models | User Manual, hs_id=161968263487, hs_path=glutamatergic-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=bit-bio ioGlutamatergic Neurons Day 14 Beta III Tubulin staining copy, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/ioGlutamatergic%20Neurons%20in%20Drug%20Discovery/bit-bio%20ioGlutamatergic%20Neurons%20Day%2014%20Beta%20III%20Tubulin%20staining%20copy.jpeg, height=1200}, year={label=2024, value=2024}, summary=<p>V11</p>
<p>无忧短视频</p>
<p>2024</p>, date_published=1707955200000, sort_date=1713225600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}, {label=ioAstrocytes, value=ioAstrocytes}, {label=Product information, value=Product information}], media_contact=<p><span>V11</span></p>
<p><span>无忧短视频</span></p>
<p><span>2024</span></p>, listing_button_label=Download}, {hs_name=CRISPRa-Ready ioGlutamatergic Neurons User Manual, hs_id=186090210329, hs_path=crispr-activation-ready-glutamatergic-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=无忧短视频-CRISPRa-ready-ioGlutamatergic-neurons-map2-staining, width=856, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/CRISPRa-Ready%20ioGlutamatergic%20Neurons/无忧短视频-CRISPRa-ready-ioGlutamatergic-neurons-map2-staining.png, height=856}, year={label=2025, value=2025}, summary=V1<br>2025<br>无忧短视频, date_published=1739404800000, sort_date=1739404800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=Product information, value=Product information}, {label=CRISPRa-Ready ioGlutamatergic Neurons, value=crispra-ready_ioglutamatergic_neurons}], media_contact=V1<br>2025<br>无忧短视频, listing_button_label=Download}, {hs_name=Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons, hs_id=161968263497, hs_path=in-conversation-with-charles-river-video-part-2, button_label=null, button_link=null, type={label=Video, value=Video}, thumbnail={alt_text=, width=687, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/CRL%20video%20posts/crl%202%20webpage%20image-2.png, height=476}, year={label=2021, value=2021}, summary=<p>Dr Marijn Vlaming | Head of Biology, et al.</p>
<p>Charles River & 无忧短视频</p>, date_published=1705017600000, sort_date=1637107200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch }, {hs_name=In Conversation with Charles River, hs_id=161968263498, hs_path=in-conversation-with-charles-river-video, button_label=Discover our ioCells portfolio, button_link=/discover-iocells, type={label=Video, value=Video}, thumbnail={alt_text=, width=834, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/CRL%20video%20posts/CRL%20video%20%231%20card%20for%20webpage%20(thinner%20gradient%20line)-1.png, height=590}, year={label=2021, value=2021}, summary=<p>Dr Marijn Vlaming <span>|</span> Head of Biology<br>Charles River</p>, date_published=1705363200000, sort_date=1636675200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=null, listing_button_label=Watch}, {hs_name=Culturing Glutamatergic Neurons | How-to Video, hs_id=161966111374, hs_path=how-to-culture-ioglutamatergic-neurons, button_label=Download the user manual, button_link=/resources/ioglutamatergic-neurons-user-manual, type={label=Video tutorial, value=Video tutorial}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/How%20to%20prepare%20tissue%20culture%20vessels%20with%20PDL-Geltrex-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Dr Kaiser Karim <span>|</span> Scientist<br>无忧短视频</p>, date_published=1705104000000, sort_date=1637020800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch now}, {hs_name=Preparing Culture Vessels for Glutamatergic Neurons | How-to Video, hs_id=161966111375, hs_path=how-to-prepare-tissue-culture-vessels-with-pdl-geltrex, button_label=Watch the next video, button_link=/resources/how-to-culture-ioglutamatergic-neurons, type={label=Video tutorial, value=Video tutorial}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/How%20to%20culture%20ioGlutamatergic%20Neurons-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Dr Kaiser Karim <span>|</span> Scientist<br>无忧短视频</p>, date_published=1705190400000, sort_date=1636934400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch now}, {hs_name=Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human iPSC-derived cells, hs_id=161968263519, hs_path=modelling-neurodevelopment-webinar-2022, button_label=Explore ioGlutamatergic Neurons, button_link=/products/nerve-cells/glutamatergic-neurons-wild-type-io1001, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/product-page/Colour%20webinar%20with%2060x%20Map2-com.jpg, height=732}, year={label=2022, value=2022}, summary=<p><span>Dr Deepak Srivastava | King鈥檚 College London<br><br></span><span></span></p>, date_published=1707436800000, sort_date=1649376000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Rethinking Developmental Biology With Cellular Reprogramming, hs_id=161968263524, hs_path=rethinking-developmental-biology-with-cellular-reprogramming, button_label=Explore ioCells, button_link=/discover-iocells, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Tech%20Nets%202023/无忧短视频_ioGlutamatergic%20Neurons_20xMAP2(red)Hoescht(blue)_day12v2.png, height=1260}, year={label=2023, value=2023}, summary=<p>Mark Kotter | CEO and founder | 无忧短视频</p>
<p>Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology | Stanford University</p>, date_published=1709164800000, sort_date=1681776000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=Cell therapy, value=Cell therapy}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}], media_contact=null, listing_button_label=Watch now}, {hs_name=Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming, hs_id=161968263525, hs_path=addressing-the-reproducibility-crisis-driving-genome-wide-consistency-in-cellular-reprogramming, button_label=Explore ioCells, button_link=/discover-iocells, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Tech%20Nets%2019th%20July%202023/无忧短视频_ioGlutamatergic%20Neurons_60xMAP2(red)Hoescht(blue)TUBB3(blue)_day4.jpg, height=1260}, year={label=2023, value=2023}, summary=<p>Dr Ania Wilczynska | Head of Computational Genomics | Non-Clinical | 无忧短视频</p>, date_published=1709769600000, sort_date=1689724800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Running Large-Scale CRISPR Screens in Human Neurons, hs_id=161968263528, hs_path=running-large-scale-crispr-screens-in-human-neurons, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Header%20images/Header%20Images%20-%20ICC%20only/Running%20Large-Scale%20CRISPR%20Screens%20in%20Human%20Neurons_email%20header.png, height=678}, year={label=2023, value=2023}, summary=<p>Emmanouil Metzakopian | Vice President, Research and Development | 无忧短视频</p>
<p>Javier Conde-Vancells | Director Product Management | 无忧短视频</p>, date_published=1710460800000, sort_date=1700524800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}, {label=CRISPR-Ready ioMicroglia, value=CRISPR-Ready ioMicroglia}], media_contact=null, listing_button_label=Watch now}, {hs_name=Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease, hs_id=183096620633, hs_path=human-ipsc-based-models-of-glial-cells-for-studying-neurodegenerative-disease, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry, width=1000, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioOligodendrocyte-like%20cells/bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry.jpg, height=1350}, year={label=2024, value=2024}, summary=Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation<br><br>In锚s Ferreira | Senior Product Manager | 无忧短视频, date_published=1732233600000, sort_date=1732233600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}], media_contact=null, listing_button_label=Watch now}])
Hoescht(blue)TUBB3(blue)_day4.jpg?width=604&name=无忧短视频_ioGlutamatergic%20Neurons_60xMAP2(red)Hoescht(blue)TUBB3(blue)_day4.jpg)
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CRISPRa-Ready ioGlutamatergic Neurons User Manual
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Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
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Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons
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Sartorius application note - Advanced in vitro Modeling of Human iPSC-derived Neuronal Mono- and Co-cultures with Microglia
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ioGlutamatergic Neurons
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ioGlutamatergic Neurons Wild Type and related disease models | User Manual
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Circadian clocks in human cerebral organoids
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Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer鈥檚 disease
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Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons
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Generating publishable neuroscience research in 12 weeks with ioGlutamatergic Neurons
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Running Large-Scale CRISPR Screens in Human Neurons
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Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication
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Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming
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Industrialising Cellular Reprogramming: Leveraging opti-ox Technology to Manufacture Human Cells with Unprecedented Consistency
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Modelling neurodegeneration: Human isogenic system to study FTD & ALS
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HNRNPH1 regulates the neuroprotective cold鈥恠hock protein RBM3 expression through poison exon exclusion
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Rethinking Developmental Biology With Cellular Reprogramming
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Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models
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Development and characterisation of a robust in vitro disease model to study tauopathies
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Cell culture hacks | human iPSC-derived glutamatergic neurons
Read this blog on glutamatergic neuron cell culture for our top tips on careful handling, cell plating and media changes to achieve success from the outset.
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ioWild Type Cells
ioGlutamatergic Neurons
cat no | io1001
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ioDisease Model Cells
ioGlutamatergic Neurons PRKN R275W/WT
cat no | io1013
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ioDisease Model Cells
ioGlutamatergic Neurons PINK1 Q456X/WT
cat no | io1079
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ioDisease Model Cells
ioGlutamatergic Neurons SNCA A53T/A53T
cat no | io1088
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ioDisease Model Cells
ioGlutamatergic Neurons PRKN R275W/R275W
cat no | io1020
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ioDisease Model Cells
ioGlutamatergic Neurons PINK1 Q456X/Q456X
cat no | io1076
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CRISPR-Ready ioCells
CRISPRko-Ready ioGlutamatergic Neurons
cat no | io1090
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Wild Type and Isogenic Disease Model cells: A true comparison.
Further your disease research by pairing our wild type cells with isogenic disease models.
